Human type I procollagen genes are located on different chromosomes.
نویسندگان
چکیده
A recombinant plasmid containing sequences complementary to human pro-alpha l(I) collagen mRNA was used for the chromosomal assignment of the pro-alpha l(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosomes with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-alpha l(I) gene with the segment 17q21 leads to qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 79 21 شماره
صفحات -
تاریخ انتشار 1982